Luc Cheung

One thing I do look back on fondly was how incredibly focused we were. Resources and time were so tight that you could feel the weight of all the things you weren’t working on. You had real conviction that the thing you were doing was the most important thing.

To pick a somewhat trivial example, at fireside chats with Mark (the predecessor to the... See more

A trick to learning a complicated topic is realizing how many complex details are a cousin of something simple. John Reed writes in his book Succeeding :

When you first start to study a field, it seems like you have to memorize a zillion things. You don’t. What you need is to identify the core principles – generally three to twelve of them – that

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Cost of sequencing a human genome 🔬 • 2001 - $95 million • 2008 - $342,502 • 2011 - $7,743 • 2023 - $200 with the new Illumina machine Cc: @PeterDiamandis @azeem @erikbryn @rtnarch

Simplicity is difficult because most of us are overcompensating for uncertainty. Adding something is easy. But removing something is hard, because it requires conviction. It’s easier to hedge against uncertainty, entertain multiple paths, and dilute your focus than to develop a strong opinion about what to exclude.