many of the quant-ities related to suffering are based on perceptions and similar uncertain infer-ences. The uncertainty will necessarily increase frustration since it means the predictions of reward often go wrong . More fundamentally, the computed reward loss can be uncertain, even illusory .
one of the latest big theories in neuroscience says that humans are fundamentally creatures of prediction, and not only is creativity not at odds with that, but it actually goes hand in hand with improving our predictive power. Life itself, in this view, is one big process of creatively optimizing prediction as a survival strategy in a universe... See more
Their finding is part of wider realization in the neuroscience community, that our brain does not simply react to what comes in through our senses. Instead, we have a predictive brain, that permanently predicts what comes next. The expected sensory input is then suppressed. We see the world from the inside out, rather than from the outside in.