sari

We can imagine an entire ‘stock market’ for a city — not r/wallstreetbets but ‘Main Street Bets’ — asset prices reflecting the growth and success (or failure) of different communal projects and efforts. We can envision how such liquidity dynamics would dramatically reduce the ‘cost of capital’ for any local ‘social’ entrepreneur and venture, unlock... See more

Give someone their start or otherwise be an inflection point. Believe in them before others do and they'll be immensely grateful. If you create the turning point in their career or personal growth, they’ll remember you forever.

What is novel about therapies that target aging is that they tend to produce improvements across the board. Normally, drugs tend to treat a single condition, leaving everything else untouched. But as aging is the breakdown of our body’s capability for self-maintenance in general, addressing that one root cause ameliorates all the conditions downstr... See more

Complexity can be tamed, but it requires considerable effort to do it well. Decreasing the number of buttons and displays is not the solution. The solution is to understand the total system, to design it in a way that allows all the pieces fit nicely together, so that initial learning as well as usage are both optimal. Years ago, Larry Tesler, then... See more

This creates a type of hub-and-spoke model, where lower acuity cases can be taken care of in these primary stroke centers and transferred to the mothership for necessary procedures, etc.