Luc Cheung

Cost of sequencing a human genome 🔬 • 2001 - $95 million • 2008 - $342,502 • 2011 - $7,743 • 2023 - $200 with the new Illumina machine Cc: @PeterDiamandis @azeem @erikbryn @rtnarch

So here's the story of how we missed Airbnb, one of the best startups to come our way in the past few years.

The Airbnb founders came out of the winter 2009 Y Combinator class. They came to see us during their time at YC. They told us about a great stunt they pulled at the Democratic Convention in Denver (in which Obama was nominated). They bought a... See more

What is impossible, however, is concentrating on two tasks at once. Multitasking forces your brain to switch back and forth very quickly from one task to another.

This wouldn’t be a big deal if the human brain could transition seamlessly from one job to the next, but it can’t. Multitasking forces you to pay a mental price each time you interrupt one... See more

The more senior the designer, the more abstract the problem they should be solving.

To break it down more tangibly, let’s look at some examples of levels and appropriate responsibilities:

Designer Lvl 1: Design a form that lets people edit their profile. Pretty scoped—assumes there is a profile, and that the solution takes the shape of a form.

Design... See more

As with other social networks that grow, Instagram broadened its formats early on to head off several format-based asymptotes. Non-square photos and videos with gradually lengthening time limits have broadened the use cases and, more importantly, removed some level of production friction.

The move to copy Snapchat's Stories format was the next giant... See more