Seth Kramer
@kramer
Seth Kramer
@kramer
fructose component of sugar and HFCS appears to have a major role in inducing fatty liver by both stimulating de novo lipogenesis and blocking β-fatty acid oxidation. Evidence suggests these effects are due to the unique metabolism of fructose by fructokinase that leads to a fall in ATP with nucleotide turnover and uric acid generation.
the writer Charles Bukowski said: ‘Some people never go crazy. What truly horrible lives they must lead.’
mice lacking both fructokinase C and A are protected from fructose-induced fatty liver,
"I was waiting for something extraordinary to happen, but as the years wasted on, nothing ever did unless I caused it.”
—Charles Bukowski