Daniel Wentsch

The writer Zadie Smith puts it better than I ever could, describing having a child as a “strange admixture of terror, pain, and delight.” Smith, echoing the thoughts of everyone else who has seriously considered these issues, points out the risk of close attachments: “Isn’t it bad enough that the beloved, with whom you have experienced genuine joy,

The reason rapamycin has so many diverse applications is thanks to a property that Sehgal had observed, but never explored, which is that it tends to slow down the process of cellular growth and division.

Try writing about why the work is important, or spend some time reflecting on times in the past where you’ve felt most connected to it.

Importantly, in an emotionally healthy childhood, plenty goes wrong. No one has staked their reputation on rendering the whole story perfect. The carer does not see it as their role to remove every frustration. They intuit that a lot of good comes from having the right, manageable kind of friction, through which the child develops their own

Thinking with AI, not by AI

If you’ve felt the tension between wanting to stay sharp and needing to stay competitive, you don’t need to choose one or the other. The cognitive capabilities that make you valuable don’t disappear when you use AI. But they can atrophy if you use it in a passive way.

So, for your next meaningful project:

1. Spend 30

A recent study from August 2025 in Nature looked at nine different medications: acetaminophen, ibuprofen, diclofenac, furosemide, atorvastatin, metformin, pseudoephedrine, temazepam, and tramadol. In the presence of ciprofloxacin, a commonly used antibiotic, ibuprofen and acetaminophen increased the mutation rates of E. coli, a common human

I like the process of choosing the words I commit to posterity on the internet. I don’t just like it, I cherish it . That’s why, when I outsourced this task to AI in an attempt to be more productive, I was left unimpressed, and gradually, I stopped trying to use LLMs altogether.

everything you are perceiving, right now, including that fabricated sense of a “center” of consciousness, is an output of your mind