zeynep sude

The lack of menstrual shedding and the immune differences in animal models of endometriosis limit the translational potential to human applications.

We identified that disease-modified macrophages exhibit increased expression of IGF-1 in an in vitro model of endometriosis-associated macrophages and confirmed expression by lesion-resident macrophages in mice and women. Concentrations of IGF-1 were elevated in peritoneal fluid from women with endometriosis and positively correlate with their pain... See more

The organoids phenocopied physiological responses of endometrial epithelium to hormones, including increased cell proliferation under estrogen and maturation upon progesterone

here is no known cure, and treatments are associated with low long-term success rates and significant side effects (Johnson et al. , 2013).

During menstruation, the functional layer of the endometrium is shed, which is followed by reepithelialization, regeneration, and cellular proliferation during the proliferative phase. Differentiation and secretory transformation of the endometrial glands occurs during the subsequent secretory phase and, if pregnancy does not occur, the entire... See more

Animal models in mice and ruminants where glandular function is suppressed are unable to support implantation and pregnancy

Endometriosis affects an estimated 190 million women (and those assigned female at birth) worldwide, with a significant personal and societal burden due to its painful and fertility-related symptoms (Nnoaham et al. , 2011; Zondervan et al. , 2020)

Primary endometrial epithelial cells cultured on hard plastic (i.e. polystyrene) dishes rapidly undergo de-differentiation (Zhou et al. , 2022) and, in the presence of serum, further lose physiological attributes (Ghosh and Sengupta, 1995) and epithelial barrier integrity, and have increased cellular senescence by the third cell passage (Arnold et... See more