dopamine and yours

“Often, depressed people say they don’t want to go out with their friends,” says Salamone. But it’s not that they don’t experience pleasure, he says – if their friends were around, many depressed people could have fun.

“Low levels of dopamine make people and other animals less likely to work for things, so it has more to do with motivation and... See more

In a series of experiments begun in the 1980s, Schultz and his colleagues showed that when monkeys first get something pleasant—in this case, fruit juice—their dopamine neurons fire most intensely when they drink the liquid. But once they learn that a cue like a light or a sound predicts the delivery of delicious stuff, the neurons fire when the... See more

In a 2017 interview, Ev Williams (the founder of Twitter), said something that has stuck with me since: “the trouble with algorithms, is that it rewards extremes. Say you’re driving down the road and see a car crash. Of course you look. Everyone looks. The internet interprets behavior like this to mean everyone is asking for car crashes, so it... See more

What dopamine is “really doing,” Berridge says, “is taking things you encounter, little cues, things you smell and hear, and if they have a motivational significance, [it] can magnify that significance,” raising the incentive to pursue them. Placing dopamine directly into the nucleus accumbens of rats, he notes, will make them work two to three... See more

Our dopamine economy, or what historian David Courtwright has called “limbic capitalism,” is driving this change, aided by transformational technology that has increased not just access but also drug numbers, variety, and potency.

Nora Volkow, director of the National Institute on Drug Abuse and a longtime researcher of this neurotransmitter, would like to set the record straight: “Dopamine is not the pleasure molecule in the simple, direct way it is typically portrayed in the media,” she says. “Its function is much more nuanced.”

They labeled the drive that dopamine seemed to induce as “wanting” and called the joy of being satiated, which did not seem to be connected with dopamine, “liking.”

“Better to get your dopamine from improving your ideas than having them validated. “ – Nat Friedman

“The problem with things that release a lot of dopamine all at once is that our brains have to compensate. But this is really the key point — our brains don’t just then bring our dopamine firing back to baseline level,” she said. “It actually pushes dopamine levels below baseline. We go into a dopamine deficit state. That’s the way the brain... See more