In an editorial accompanying Griffiths’s paper, the University of Chicago psychiatrist and drug abuse expert Harriet de Wit tried to address this tension, pointing out that the quest for experiences that “free oneself of the bounds of everyday perception and thought in a search for universal truths and enlightenment” is an abiding element of our hu

One of the most interesting things about a psychedelic experience is that it sharpens one’s sensitivity to one’s own mental states, especially in the days immediately following. The usual seamlessness of consciousness is disturbed in such a way as to make any given state—mind wandering, focused attention, rumination—both more salient and somewhat e

In the psychiatric world, we see addictions, obsessions, compulsions, and delusions all coming down to this issue of cognitive rigidity. Given their ability to loosen cognitive strictures, this is where psychedelics can really shine.