How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence

Quantum mechanics holds that matter may not be as innocent of mind as the materialist would have us believe. For example, a subatomic particle can exist simultaneously in multiple locations, is pure possibility, until it is measured—that is, perceived by a mind. Only then and not a moment sooner does it drop into reality as we know it: acquire fixe

Perhaps the most striking discovery of Carhart-Harris’s first experiment was that the steepest drops in default mode network activity correlated with his volunteers’ subjective experience of “ego dissolution.” (“I existed only as an idea or concept,” one volunteer reported. Recalled another, “I didn’t know where I ended and my surroundings began.”)

over time, we tend to optimize and conventionalize our responses to whatever life brings. Each of us develops our shorthand ways of slotting and processing everyday experiences and solving problems, and while this is no doubt adaptive—it helps us get the job done with a minimum of fuss—eventually it becomes rote. It dulls us. The muscles of attenti

“Individuals transcend their primary identification with their bodies and experience ego-free states,” one of the researchers was quoted as saying. They “return with a new perspective and profound acceptance.”

Patrick talked about his body and cancer “as [a] type of illusion.” It also became clear that, psychologically at least, Patrick was doing remarkably well in the aftermath of his session. He was meditating regularly, felt he had become better able to live in the present, and “described loving [his] wife even more.” In a session in March, two months

If a therapy contains an implicit theory of the disorder it purports to remedy, what might the fact that psychedelic therapy seems to address so many indications have to tell us about what those disorders might have in common? And about mental illness in general?

Andrew Solomon, in his book The Noonday Demon: An Atlas of Depression, traces the links between addiction and depression, which frequently co-occur, as well as the intimate relationship between depression and anxiety. He quotes an expert on anxiety who suggests we should think of the two disorders as “fraternal twins”: “Depression is a response to

Western science and modern drug testing depend on the ability to isolate a single variable, but it isn’t clear that the effects of a psychedelic drug can ever be isolated, whether from the context in which it is administered, the presence of the therapists involved, or the volunteer’s expectations. Any of these factors can muddy the waters of causa

This, I think, is the great value of exploring non-ordinary states of consciousness: the light they reflect back on the ordinary ones, which no longer seem quite so transparent or so ordinary. To realize, as William James concluded, that normal waking consciousness is but one of many potential forms of consciousness—ways of perceiving or constructi