The organoids phenocopied physiological responses of endometrial epithelium to hormones, including increased cell proliferation under estrogen and maturation upon progesterone. Moreover, the human endometrial organoids replicated the menstrual cycle under hormonal treatment at both the morpho-histological and molecular levels. Together, we... See more

The organoids phenocopied physiological responses of endometrial epithelium to hormones, including increased cell proliferation under estrogen and maturation upon progesterone

Human endometrial organoids can be used to answer questions about uterine/placental cross-talk during placentation, and will provide a system for studying the pathogenesis and treatment of common conditions affecting women, such as endometriosis and endometrial cancer.