Brad Barrish

by far the most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments.

It’s mediocre tools that we have to watch out for. They quietly and persistently corrupt our intent and force us to work harder on the parts that don’t matter as much.

To really like my work I have to look at it with different eyes. I have to forget everyone who did it better or faster, and remind myself that no one has ever done it quite the way I have. I have to remind myself that the people I compare myself to probably compare themselves to others and that if they let their self-doubt keep them from creating... See more

Big or small, old or new — or even hardware or software. It’s always true: underpromising and overdelivering is always the path to delight, but also always devilishly difficult to pull off. That’s the game.

It turns out that the best place for personal AIs to run is on a computer. Maybe a virtual computer in the cloud, but ideally your computer. That way they can see the docs that you can see, and use the tools that you can use, and so what they want is not APIs (which connect webservers) but little apps they can use directly. CLI tools are the... See more

“Humans of tomorrow will be AI orchestrators” is like saying, in the 90s, “Workers of tomorrow will be computer operators.” That would have seemed crazy, since most people didn’t yet see the need for having an email account. But it turned out to be a fact. Everyone has a computer on their desk or in their hand and they couldn’t do their job without... See more