Sublime

Lysergic acid diethylamide, or LSD-25, was the twenty-fifth in a series of ergot derivatives synthesized in 1938 by Dr. Albert Hofmann, a Swiss chemist working for Sandoz laboratories.

In the fall of 1938, Hofmann made the twenty-fifth molecule in this series, naming it lysergic acid diethylamide, or LSD-25 for short. Preliminary testing of the compound on animals did not show much promise (they became restless, but that was about it), so the formula for LSD-25 was put on the shelf.

Heroic dose: Ethnobotanist Terence McKenna coined the term “heroic dose,” which is often equated to 5 or more grams of mushrooms or more than 400 mcg of LSD. James doesn’t recommend this brute-force dosing, which McKenna described as “sufficient to flatten the most resistant ego.” Jim feels that you don’t remember anything, nor do you bring anythin

LSD appears to disable such conventionalized, shorthand modes of perception and, by doing so, restores a childlike immediacy, and sense of wonder, to our experience of reality,