Sublime
An inspiration engine for ideas
Today, we report Germinal, a method for efficient de novo antibody design, with @santimillef and @SynBioGaoLab.
Germinal achieves success rates of 4-22% across diverse epitopes.
We make the work fully open, without doing lame things like posting a preprint without methods. š§µ... See more
Iām sharing the following details that may be useful to you:
(1) Plasmid Full Name:
pTRE3GBi_EF1A_Tet3G_IRES_Puro-VHH hFBXW11-mCherry
or pTRE-BI-hGRAD
> Bacterial Resistance: Ampicillin.
> Addgene Link: https://www.addgene.org/207837/
(2) Reference Paper:
https://rupress.org/jcb/article/223/2/e202304030/276463/hGRAD-A-
... See more
ššIntroducing AgentRxiv: a framework where autonomous research agents can upload, retrieve, and build on each otherās research.
AgentRxiv takes your research direction and progressively outputs research, building on its previous work with each new paper!
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š§¬š 10 Books to Learn Synthetic Biology
The field is so broad and moves so fast ā DNA synthesis, gene circuits, protein design! ā that it can be hard to know where to get started.
Here are the books that I recommend, in order. š§µ
Niko McCarty.x.com
If you're looking for labs working on Protein Design, we've put together a list based on our best knowledge. The initial list came from @Zuricho_zbzt, and with a bit of help from me, we've now got it up on GitHub. Feel free to suggest any labs we might have missed!
https://t.co/21YP6rQGJV
Recently we learned how to read DNA to decipher gene expression grammar directly from genomes. Now it is possible to write entire genes with defined gene expression levels virtually in any organism! Many thanks to amazing work by @JanZrimec @Xiaozhi_Fu https://t.co/403Q1pdEYz
Aleksej Zelezniakšŗš¦x.comIs DNA all you need?
In new work, we report Evo, a genomic foundation model that learns across the fundamental languages of biology: DNA, RNA, and proteins. Evo is capable of both prediction tasks and generative design, from molecular to whole genome scale. https://t.co/BPo9ggHhmp
Patrick Hsux.com