Sublime
An inspiration engine for ideas
Mercer_Pub 248
The study describes the development of a continuous evolution system to engineer small degron tags that can be inserted into endogenous genes and selectively degrade proteins using specific small molecules.
LinkAlready a physician, Bradner went back for further study in chemistry with the goal of developing targeted drugs that can disable cancer cells’ growth at the molecular level. From the beginning,
Joel Gurin • Open Data Now: The Secret to Hot Startups, Smart Investing, Savvy Marketing, and Fast Innovation (Business Books)
Ok this paper is bonkers and I love it https://t.co/uWQzQmRKKw https://t.co/OLTskgkEAn
Are Blockchains Decentralized? Unintended Centralities in Distributed Ledgers
The report investigates the true decentralization of blockchains, highlighting various forms of centralization, vulnerabilities in consensus protocols, and the implications for security and immutability in networks like Bitcoin and Ethereum.
blog.trailofbits.com
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.” https://t.co/gYrdFFcD4T
If you're looking for labs working on Protein Design, we've put together a list based on our best knowledge. The initial list came from @Zuricho_zbzt, and with a bit of help from me, we've now got it up on GitHub. Feel free to suggest any labs we might have missed!
https://t.co/21YP6rQGJV
Trends – Artificial Intelligence (AI) – May 2025 – BOND
The document analyzes rapid growth and transformative trends in artificial intelligence, highlighting unprecedented user adoption, technological advances, global competition, enterprise AI integration, and associated benefits and risks shaping the future.
bondcap.com
Bob's Med Chem Fact of the Day:
Shionogi's new SARS-CoV-2 3CL protease inhibitor is a great example of how obtaining ADME info on screening hits can be helpful.
They took a hit with modest potency (8 uM triazine!) but promising PK profile, and quickly obtained a candidate.... See more