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Several groups of scientists made mutations in the Cas9 protein that incapacitated its DNA-cutting activity but did not interfere with its ability to bind a single-guide RNA. They dubbed their creation “Dead Cas9” for short. They now found that by coupling a variety of other proteins to Dead Cas9, they could deliver those proteins to specific sites
... See moreThomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
Synchronized long-read genome, methylome, epigenome and transcriptome profiling resolve a Mendelian condition - Nature Genetics
nature.com
I no longer believe that incremental fixes are enough. Science publishing must be built anew. I help oversee billions of dollars in funding across several science and technology organizations. We are expanding our requirement that all scientific work we fund will not go towards traditional journal publications. Instead, research we support should b... See more
Scientific Publishing: Enough is Enough
While scientific progress, then, proceeds by curiously exploring adjacent possibilities, preference is given to work closely tied to existing science and conducted by a privileged subset of scientists.
Perry Zurn, Dani S. Bassett • Curiosity and Networks of Possibility
Peer review
Shahar Refael Oriel • 2 cards
‘There is one new paper in particular that has really thrown the issue back into the melting pot,’ he wrote. ‘A team of scientists finds that unlike SARS, this virus showed very little rapid adaptation/evolution in the early weeks of the epidemic, implying it was already settled into its final form.
Matt Ridley • Viral: The Search for the Origin of COVID-19
Learning Science
Bhaumik Patel and • 3 cards