Sublime

First mushroom trip data is out: my brain activity. Dose: 5 g dried Psilocybe cubensis (B+ strain) Containing 24.9 mg psilocybin Psilocybin longevity experiment. What we see in the brain: + brain activity data mirror my subjective... See more

Robin Carhart-Harris and colleagues have argued that the Freudian primary process is characterised by high levels of entropy. The primal, infant brain state is disorganised; however, as the infant matures, organisation is the inevitable by-product of a system in which free energy is minimised. The ensuing (low entropy) 'structure' that emerges

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Specially trained psychiatrists and psychologists are now administering hallucinogens and other potent psychotropic agents (psilocybin, ketamine, ecstasy) as mental health remedies. Administering limited doses (one to three) of psychedelics interspersed with multiple sessions of talk therapy over many weeks has become the modern equivalent of

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Additionally, a single dose of DOI leads to changes in chromatin organization, particularly at enhancer regions of genes involved in synaptic assembly that stretch for days after the psychedelic exposure. These DOI-induced alterations in the neuronal epigenome overlap with genetic loci associated with schizophrenia, depression, and attention... See more

A single dose of psilocybin changes the brain. 🧵1/12 https://t.co/Vlrj1LuebS