Sublime
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Excellent blog post by @jacobkimmel on why pharma progress has slowed down over the last many decades, and why some people are optimistic about a big speedup over the next few years.
Eroom's Law (coined by @jackscn) says that the number of drugs per billion dollars decline two-fold every nine years.
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Nice article (h/t @KRHornberger ) explaining why current AI approach is unlikely to help drug discovery, and particularly $rxrx because they are looking at the least impactful stage; generating hits. https://t.co/HKiP6SbdiP... See more
why don’t we have more medicines?
inventing medicines has grown less efficient, limited by our knowledge of biological targets
for the 1st time, AI & genomics have the potential to make this knowledge abundant – one of the largest potential impacts of the intelligence age.
Small-molecule discovery through DNA-encoded libraries https://t.co/xTB27Irfl2
This new review discusses small molecules discovered by using DELs, covering initial identification, optimization and validation of biological properties such as suitability for clinical applications https://t.co/D34shEPIPi
Structure-based drug discovery with deep learning - A timely review! https://t.co/sGnwidneY7
Marwin Seglerx.com