Sublime

Excellent blog post by @jacobkimmel on why pharma progress has slowed down over the last many decades, and why some people are optimistic about a big speedup over the next few years. Eroom's Law (coined by @jackscn) says that the number of drugs per billion dollars decline two-fold every nine... See more

Nice article (h/t @KRHornberger ) explaining why current AI approach is unlikely to help drug discovery, and particularly $rxrx because they are looking at the least impactful stage; generating hits. https://t.co/HKiP6SbdiP https://t.co/DmW90LHTou

why don’t we have more medicines? inventing medicines has grown less efficient, limited by our knowledge of biological targets for the 1st time, AI & genomics have the potential to make this knowledge abundant – one of the largest potential impacts of the intelligence age.

Small-molecule discovery through DNA-encoded libraries https://t.co/xTB27Irfl2 This new review discusses small molecules discovered by using DELs, covering initial identification, optimization and validation of biological properties such as suitability for clinical applications https://t.co/D34shEPIPi

Western Biotech’s “DeepSeek Moment” – China’s Rise in Pharma Innovation The WSJ article opens with how Summit Therapeutics’ cancer drug, licensed from China’s Akeso, outperformed Merck’s $30B Keytruda. But apparently this isn't all that special — Chinese companies now account for 31% of major pharma licensing deals, up... See more

Amen! A must read: https://t.co/6DpnniDltE @ACSBioMed #DrugDiscovery https://t.co/gQ0Y2EWYwG