Sublime

Today we report in @NatureComms the development of compact zinc-finger base editors that edit mitochondrial or nuclear DNA in human cells and in animals, building on our previous development of TALE BEs that enabled the first precise editing of mtDNA. 1/8 https://t.co/bK2fi3yJgi... See more

Very interesting new preprint from Vinarsky lab on 'Behavioral transcriptomics', which combines live-cell imaging, photoconversion, and scRNA-seq in order to learn molecular signatures of physiological cellular behaviors: https://t.co/4OEPlizuxp... See more

Engineered plasma cells as a long-term biologic drug delivery platform 🧬 We're starting to make pretty advanced biologic therapies. Bi-specific T-cell engagers (BiTEs) are a great example. Let's look at Blinatumomab, a BiTE approved to treat B-cell acute lymphoblastic leukemia (B-ALL). This... See more

GenoFig: a user-friendly application for the visualisation and comparison of genomic regions https://t.co/5jgFBEZj6P... See more

We prompted ESM3 to generate fluorescent proteins with a chain of thought. In the first plate, shown below, we were intrigued to find B8. While very dim, 50x dimmer than natural GFPs, it was far from any known GFPs -- 43% of its sequence differs from the closest natural protein. Continuing t... See more

I take back what I said, the latest Baker lab paper achieves picomolar affinity with two rounds of design, 96 sequences expressed each round. https://t.co/IpX0FUvrzL