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The idea was to short-circuit the production of a protein by introducing an RNA that was complementary (“antisense”) to its mRNA. The antisense strand would base-pair with the mRNA of interest, covering up the codons and preventing protein synthesis.
Thomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
Ok this paper is bonkers and I love it https://t.co/uWQzQmRKKw https://t.co/OLTskgkEAn
RNA therapeutics landscape (private and public). From Cowen's recent RNA review. https://t.co/UzJbS9E2AR
Just learned that the vast majority of the Shannon information in a cell is likely contained is in the transmembrane ion gradient. Where was this *information* when I was being taught the central dogma, because this makes the central dogma look completely bogus & incomplete.
amelie_schreiberx.cominterference (RNAi).
Thomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
All the cargoes of RNA/DNA companies are essentially the easy part. The great limiting rate is to find a cell type specific delivery system outside of the liver. And then the catch…if I had such a system? I would always use an siRNA first rather than #GeneEditing. #rnai #CRISPR
Ali Mortazavix.com