Sublime

lost microbes, bacterial species that might have vanished from the modern human microbiome.

microbe lost by most modern people,

there are good reasons to think that in the arms race between doctors and germs, doctors run faster.

the last fifty years represent an unprecedented acceleration of microbial disruption in the human body. But such changes got their start many thousands of years earlier.

microbiome disruptions most modern humans have experienced often are confined to the colon,

The health of the human body is ultimately dependent on the health of habitat and community. And yet, this connection is almost universally ignored in modern health disciplines where biomedical reductionism rules the day. Human health and environmental preservation are treated as entirely different fields, with miles of empty space between them.

The human oral microbiome has clearly changed.

The theory is this: some infectious agents–notably those that coevolved with us–protect us from immune-related disorders.