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The First Principle The only proven strategy for slowing aging and prolonging lifespan is moderate calorie restriction in the environment of micronutrient excellence. The Second Principle A diet has to be hormonally favorable to enable maximal lifespan. The Third Principle Optimal exposure to all macronutrients and micronutrients humans require is
... See moreJoel Fuhrman M.D. • Eat for Life: The Breakthrough Nutrient-Rich Program for Longevity, Disease Reversal, and Sustained Weight Loss

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The e2 variant of APOE, on the other hand, seems to protect its carriers against dementia—and it also turns out to be very highly associated with longevity. According to a large 2019 meta-analysis of seven separate longevity studies, with a total of nearly thirty thousand participants, people who carried at least one copy of APOE e2 (and no e4)
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