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Let’s talk about proteins whose abundance is generally independent from the abundance of the transcripts that templates them.
Give examples.
Prof. Nikolai Slavovx.com
When E. coli becomes burdened with a lot of damaged DNA, LexA falls off the lo-fi polymerase genes. Now the lo-fi polymerases help repair E. coli’s DNA. And because they do a less accurate job, they leave behind
Carl Zimmer • Microcosm: E. coli and the New Science of Life
influential researchers
Wesley Finck • 1 card
5/n By projecting human IDRs into the high-D space of conserved molecular features, aka “evolutionary signatures” 📊, we crafted a map 🗺️ of the human IDR-ome. Half of our IDR clusters show GO enrichments, hinting at shared biological functions or cellular locations. https://t.co/ssx8P32E8U
When we do, we assume the politicians are clients in a patron–client relationship, and we assume their obligations will cloud their impartial judgment.
Jessica C. Flack • Worlds Hidden in Plain Sight: The Evolving Idea of Complexity at the Santa Fe Institute, 1984–2019 (Compass)
Genomes are sets, not just strings.
Protein Set Transformer trains on >100k viral genomes, treating each genome as an attention-weighted set of protein embeddings.
It links distant viruses, rescues “hypothetical” proteins, and even nails host species, laying groundwork for foundation LMs in ... See more
during a crisis E. coli’s mutation rates could soar a hundred-or even a thousandfold. Several studies identified E. coli’s lo-fi polymerases as the enzymes that created these extra mutations.