Sublime

You may have heard of this gene, which is called APOE, because of its known effect on Alzheimer’s disease risk. It codes for a protein called APOE (apolipoprotein E) that is involved in cholesterol transport and processing, and it has three variants: e2, e3, and e4. Of these, e3 is the most common by far, but having one or two copies of the e4

women get older, they tend to experience a negative triple whammy, an increase in the risks of three interrelated adverse reproductive outcomes—infertility, miscarriage, and chromosomal abnormalities (including trisomy 21, which is the presence of three copies of chromosome 21, also known as Down syndrome).

O genoma como uma máquina autorreplicadora coopta a fisiologia, o metabolismo, o comportamento e a identidade de uma célula, e o resultado é uma doença que muda de forma e, apesar de avanços significativos, desafia nossa capacidade de tratá-la ou curá-la.

Genes, which carry the codes to build proteins, are physically located in a double-stranded, helical molecule called deoxyribonucleic acid (DNA), which is further packaged in human cells into skein-like structures called chromosomes. As far as we know, DNA is present inside every living cell (unless it has been ejected from the cell).

‘balancer’ chromosomes. These chromosomes contain multiple inverted sequences, meaning that big chunks have been cut out, flipped around and reinserted backwards.