
The Song of the Cell

First, we arose from a single-celled embryo. And second, from that cell came multiple cells—those that populate your body and mine.
Siddhartha Mukherjee • The Song of the Cell
pathology—the study of human diseases, and their causes—
Siddhartha Mukherjee • The Song of the Cell
By decoding, I mean that molecules within a cell read certain sections of the genetic code, like musicians in an orchestra reading their parts of a musical score—the cell’s individual song—thereby enabling a gene’s instructions to become physically manifest in the actual protein.
Siddhartha Mukherjee • The Song of the Cell
And finally, a cell is a dividing machine. Molecules within the cell—proteins, again—initiate the process of duplicating the genome. The internal organization of the cell changes. Chromosomes, where the genetic material of a cell is physically located, divide. Cell division is what drives growth, repair, regeneration, and, ultimately, reproduction,
... See moreSiddhartha Mukherjee • The Song of the Cell
the 1670s, Antonie van Leeuwenhoek, a cloth merchant in Delft, needed an instrument to examine the quality and integrity of thread.
Siddhartha Mukherjee • The Song of the Cell
Genes, which carry the codes to build proteins, are physically located in a double-stranded, helical molecule called deoxyribonucleic acid (DNA), which is further packaged in human cells into skein-like structures called chromosomes. As far as we know, DNA is present inside every living cell (unless it has been ejected from the cell).
Siddhartha Mukherjee • The Song of the Cell
And that behavior, in turn, manifests as the behavior of the organism. The metabolism of an organism reposes in the metabolism of the cell. The reproduction of an organism reposes in the reproduction of a cell. The repair, survival, and death of an organism repose in the repair, survival, and death of cells. The behavior of an organ, or an organism
... See moreSiddhartha Mukherjee • The Song of the Cell
Life’s definition, as it stands now, is akin to a menu. It is not one thing but a series of things, a set of behaviors, a series of processes, not a single property. To be living, an organism must have the capacity to reproduce, to grow, to metabolize, to adapt to stimuli, and to maintain its internal milieu. Complex, multicellular living beings al
... See moreSiddhartha Mukherjee • The Song of the Cell
What is a cell, anyway? In a narrow sense, a cell is an autonomous living unit that acts as a decoding machine for a gene. Genes provide instructions—code, if you will—to build proteins, the molecules that perform virtually all the work in a cell. Proteins enable biological reactions, coordinate signals within the cell, form its structural elements
... See more