Sublime
An inspiration engine for ideas
Wonder what that secretive longevity company funded w/ $3B from @JeffBezos and @yurimilner has been working on?
SCOOP: @altos_labs latest public program is an oligonucleotide inhibiting the retrotransposon LINE-1 to treat progeria. https://t.co/ynsQL2sT8X
Ok this paper is bonkers and I love it https://t.co/uWQzQmRKKw https://t.co/OLTskgkEAn
Mercer_Pub 248
The study describes the development of a continuous evolution system to engineer small degron tags that can be inserted into endogenous genes and selectively degrade proteins using specific small molecules.
LinkToday in @ScienceMagazine, together with my former colleagues at NIBR, we report the discovery and characterization of first molecular glue degraders of the WIZ transcription factor (TF) for fetal hemoglobin derepression and therapeutic consideration in Sickle Cell Disease. 1/10
https://t.co/rJypcBl75C
Jay Bradner, M.D.x.comAlready a physician, Bradner went back for further study in chemistry with the goal of developing targeted drugs that can disable cancer cells’ growth at the molecular level. From the beginning,
Joel Gurin • Open Data Now: The Secret to Hot Startups, Smart Investing, Savvy Marketing, and Fast Innovation (Business Books)
Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome.
The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited.
The problem with... See more
Jeff Karp is a scientist inspired by elegance … and jellyfish. As an associate professor at Harvard Medical School, Karp’s research focuses on using bio-inspiration—inspiration from nature—to develop new solutions for all types of medical challenges. His self-named Karp Lab has developed innovations such as a device inspired by jellyfish tentacles
... See moreRohit Bhargava • Non-Obvious 2017: How To Think Different, Curate Ideas and Predict The Future
Today we report in @NatureBiotech the development of dual-AAV in vivo delivery systems for prime editors that can support efficient prime editing in multiple organs such as brain, liver, and heart.
1/4 https://t.co/lSInTkYBiv