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Diseases have global networks of stakeholders: Imagine a new insulin treatment funded, governed, and owned by diabetics. Our marketplace connects researchers with patients to enable this.

You need two components to build a successful e-commerce business, the software that runs the online store and the marketing to get customers to come to the store. A large part of what makes marketplaces like Amazon so attractive to merchants is that it provides both components.

The decentralized web should be conceptualized as three distinct spheres: one for speculators (trade), one for participants (earn), and one for consumers (burn). The speculative web encompasses any risky activity where one outlays capital for the purpose of earning a financial return. The participant web involves anyone building or participating in... See more

“There’s no doubt in my mind that we’re going to go through a very similar journey where even the concept of what a podcast or audio actually is will become re-imagined.”

People will struggle to structure their time now that virtual activities carry more social weight than they did in the past. IRL hangouts have more tangible controls and barriers to entry that prevent people from engaging endlessly, and physical anchors that help form habits and routines. Without that, people are going to either burn out or quickly... See more

So the choice is now: “I’m going to find this niche obscure thing, or I’ll get the mass market thing.” It’s either Paul Skallas or Malcolm Gladwell. Aesop Rock or ASAP Rocky. Boutique brand or Amazon. You get the idea.