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What had more important ramifications for the company’s future was Santos’ singular focus on press, with nearly all profits — at least in the early days — going to marketing.

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Put simply, it’s the combination of scale and privacy. Apple’s focus on privacy got them in the door with healthcare companies, and their scale allows healthcare providers to tap into their customer base for large scale research studies that make the relationship mutually beneficial.

Conventional medicine is certainly good for some scenarios, such as trauma, but alternative medicine is superior for treating chronic diseases (since the cause is usually lifestyle-related)

Conversely, as Casper discovered, there is no particular reason why a company selling consumer products ‘but on the internet’ should have any higher margins than anyone else. It seems quite likely that the great consumer reset underway now will see the creation of all sorts of new retailers, brands and products, but it doesn't follow that they will... See more

The first thing they’ve done is make sure as many readers as possible are aware that they’re using Substack. When your login information and credit card is stored, and the sites all look pretty similar and function the same way, it reduces the friction of signing up and paying for new newsletters. This is why from the beginning it’s been so... See more

When we look back over the past 100 years, traditional commerce (and the culture it indirectly endorsed) was primarily curated by a single person’s point-of-view. Even when commerce moved online, to places like Amazon or Farfetch, retailers still controlled the types of things consumers purchased. Online commerce didn’t innovate a new shopping... See more

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