Focus, as Steve Jobs said, is about saying no. The only dangerous competitors are focused ones. Ergo there are things that even the most dangerous competitors say no to, and it would be worth thinking explicitly about what those are.

Cost of sequencing a human genome 🔬 • 2001 - $95 million • 2008 - $342,502 • 2011 - $7,743 • 2023 - $200 with the new Illumina machine Cc: @PeterDiamandis @azeem @erikbryn @rtnarch

Some of the best startup ideas live in a grey area of legality. Airbnb, Uber, Lyft, YouTube, Coinbase were all somewhere between questionable and flat-out illegal in their early days. One reason for this is that incumbents cannot take any legal risk on a new initiative. Even if… Show more

Companies should consider bringing on automation engineers. Their job would be to use AI to speed up company workflows. - write reusable prompts - make custom ChatGPT plugins - create AI agents for company processes - build AI extensions Massive productivity gains to be had.

Focus is good. But so is following your enthusiasm. All my most valuable work has happened when I wasn’t doing what I was “supposed” to be doing. No easy answers here, but I do think enthusiasm is more important than most people realize, and should be taken more seriously.

After 10 Years of Buildi...

Winners expect to win.

What YC taught me about how startups fail

Some of my biggest surprises when researching paths to PMF for top B2B companies: 1. If you build it, they *will* come—if you have strong product-market fit.

Taught myself iOS dev and SwiftUI over a weekend with ChatGPT & now using Cursor to successfully build an entire app for my startup. Can't think of any other tool that's upgraded my human capabilities as much as GPT4. All you need to build the future is motivation.