Johanna

A great team and a great market are both critically important—you have to have both. The debate about which is more important is silly.

Treat your values as articles of faith. Screen candidates for these values and be willing to let an otherwise good candidate go if he is not a cultural fit.

We pay lip service to the idea of hiring the best people in the world — but in reality, we’re only hiring the best people who happen to be close by. Call me crazy, but I think if we’re going to talk about hiring the best talent available, we should actually try to do that. This means letting go of the idea, at least in IT work, that people need to... See more

Most scientists strongly favor more research funding. They like to portray science in a positive light, emphasizing benefits and minimizing negatives. While understandable, the evidence is that science has slowed enormously per dollar or hour spent. That evidence demands a large-scale institutional response. It should be a major subject in public... See more

No blinding. Experiments must have a test and a control arm. “Blinding” is when the researcher doesn’t know whether the subject they are analyzing (be it proteins, cells, mice, or human subjects) is the test or the control. Results are more reliable if the researcher is blinded, and this is standard part of clinical trials, but is often not... See more

The most counterintuitive secret about startups is that it’s often easier to succeed with a hard startup than an easy one. A hard startup requires a lot more money, time, coordination, or technological development than most startups. A good hard startup is one that will be valuable if it works (not all hard problems are worth solving!).

If you do not work on an important problem, it's unlikely you'll do important work. It's perfectly obvious. Great scientists have thought through, in a careful way, a number of important problems in their field, and they keep an eye on wondering how to attack them. (...) By important I mean guaranteed a Nobel Prize and any sum of money you want to... See more

Throughout my career I’ve noticed that when I work about 4-5 hours on something, I’m done. Regardless of whether I’ve allocated 6 or 8 or 10 hours to it, I either finish my tasks, or I run out of runway to finish them. Most of the time spent after that is just obsessive tweaking.