Joey DeBruin
@joeydebruin
Helping communities build public knowledge online. Founder @withBackdrop. Past/current product/advisory roles @Benchling @ResearchGate @Forefront__ @SeedClub
Joey DeBruin
Early-stage venture capital investments take a long time to come to fruition. These or other YC companies from after Graham’s tenure may yet prove to be economically and culturally important like their forerunners. The evidence so far, however, suggests that their impact is well below that of earlier YC companies of similar age, in spite of their h... See more
The downside of lead generation businesses is that they can be a race to the bottom if they're in a crowded and competitive market. The barriers to entry are essentially aggregating supply (i.e. buyers of leads or businesses willing to pay for new customers) so there is little in the way of defensibility. The other downside is that they are very tr... See more
Marketplaces, Lead Generation, and Brokerages
There may be good reason to be optimistic about non-'scientists' taking part in science....Innocentive creates prizes to incentivise a distributed global network to solve specific problems for organisations who can't solve those problems in-house. Problems can be highly technical (see image below), and span across many domains. I will reuse Michael... See more
Oliver Hunt • Building a 21st century interface for science
This is great, though it still acts primarily as a sort of summer camp for entrepreneurship hopefuls, with a tight deadline in which they need to form teams, crack ideas and go to work. Goal orientedness is kind of the name of the game and the grant itself is de minimis .
If the program was ostensibly longer and/or more diverse in its intake this co... See more
If the program was ostensibly longer and/or more diverse in its intake this co... See more
Rohit Krishnan • On Medici and Thiel
How to Get and Evaluate Startup Ideas | Startup School
youtube.comSoftware is expensive to create. You have to pay people to create it, maintain it, and distribute it. Because software is expensive to create, it has to make money. And we pay for it–software licenses, SaaS, per seat pricing, etc. Software margins have historically been an architectural envy–90+% margins and zero marginal cost of distribution.
Software is expensive because developers are expensive. They are skilled translators–they translate human language into computer language and vice-versa. LLMs have proven themselves to be remarkably efficient at this and will drive the cost of creating software to zero. What happens when software no longer has to make money? We will experience a Cambrian explosion of software, the same way we did with content.
Non consensus approaches to picking businesses
Non consensus and right
How to de-risk building a social network
The components that have the most engineering scope tend to be wholly reusable—such as the friendfinder & invite system. The fastest way to arrive at an app that resonates is to run rapid experiments by only changing the interaction model
Just as much as our job is to build something genuinely useful, something which really does make people’s working lives simpler, more pleasant and more productive, our job is also to understand what people think they want and then translate the value of Slack into their terms.
Building 0-1 and