Is there a way to cultivate curiosity? To start with, you want to avoid situations that suppress it. How much does the work you're currently doing engage your curiosity? If the answer is "not much," maybe you should change something.
"A well-fed man keeps and calmly gives forth his infinitesimal portion of eternity. It sounds big in the summer night. And it is, as it always was down the ages, when there was a man with something to tell, and ones, quiet and wise, to listen." - Ray Bradbury
Meaninglessness is boring. Boredom can be described as a meaning withdrawal, in analogy with drug withdrawal, as a discomfort that tells us that our need for meaning is not being met.
What project would you be happy to devote 50 years of your life to, despite (or because of) it only being 10% done when you die?
Ht @hannu @gwern and Antoni Gaudi for inspiring the question