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Using Cortisol & Adrenaline to Boost Our Energy & Immune System
Long-term stress invokes positive feedback loops triggering over-eating. Ashwaganda can decrease cortisol levels but can have averse effects with habitual use. Apigenine can calm the nervous system. Both can be infested before bed.
Andrew Huberman • Using Cortisol & Adrenaline to Boost Our Energy & Immune System
Adrenaline protects you from infections and activated neuroplasticity in the brain. When you sense a stressor (wound, threat) the sympathetic chain ganglia and adrenals (body) and the locus cerulius (brain) release adrenaline all over the body.
Andrew Huberman • Using Cortisol & Adrenaline to Boost Our Energy & Immune System
Fasting releases ghreline, which binds to receptors that normally bind to growth hormone releasing hormone triggering the release of growth hormones.
Andrew Huberman • Using Cortisol & Adrenaline to Boost Our Energy & Immune System
Their net effect is to increase energy.
Andrew Huberman • Using Cortisol & Adrenaline to Boost Our Energy & Immune System
The increase of epinephrine after the learning triggers the neuroplasticity. It primes the hippocampus to encode the prior learned content. The optimal strategy would be a 90 minute bout of learning, trigger epinephrine, bout of NSDR.
Andrew Huberman • Using Cortisol & Adrenaline to Boost Our Energy & Immune System
Cortisol is derived from colestoral and is a steroid hormone like the sex hormones, but is their competitive partner. Sex hormones and cortisol compete for colestoral depending on your state. CRH is made in the Brain and causes the pituitary to release ACTH, which triggers the a drenals to release cortisol. Cortisol motivates movement and satiety.
Andrew Huberman • Using Cortisol & Adrenaline to Boost Our Energy & Immune System
Bombesin: Stress liberates bombesin, which reduces eating.
Andrew Huberman • Using Cortisol & Adrenaline to Boost Our Energy & Immune System
Make sure your peak in cortisol is when you wake up by getting sunlight. Stressors and unpleasant events trigger the release of adrenaline and cortisol through the day, but they need to be brief. If you struggle with alertness, it can be beneficial to deliberately increase the release through stressors like HIIT, cold exposure.
Andrew Huberman • Using Cortisol & Adrenaline to Boost Our Energy & Immune System
Cortisol can cross the blood-brain barrier (adrenaline cannot). This means the body can enter states of alertness without affecting the brain. Cold water and breathing protocols (Tumo, Wim Hoff Breathing) can trigger the release of Adrenaline while trying to calm yourself. You want to move through this calmly. Epinephrine released from the adrenal ... See more
Andrew Huberman • Using Cortisol & Adrenaline to Boost Our Energy & Immune System
Whenever we are fasting we are putting ourself on the edge of stress and alertness due to increased epinephrine and cortisol. If you are already highly stressed this can have averse effects.