Just a moment...
cell.comSaved by Behruz Davletov
Just a moment...
Ageing is not driven by mutations in genes accumulating over time, but by changes in gene activity – epigenetics.
Nick Lane • Transformer: The Deep Chemistry of Life and Death
Yet I believe that such an answer exists—a cause of aging that exists upstream of all the hallmarks. Yes, a singular reason why we age. Aging, quite simply, is a loss of information.
David A. Sinclair, Matthew D. LaPlante • Lifespan: Why We Age—and Why We Don't Have To
Our bodies accumulate lipofuscin and oxygen free-radical damage and random DNA mutations and numerous other microcellular problems. The process is gradual and unrelenting. I asked Silverstone whether gerontologists have discerned any particular, reproducible pathway to aging. “No,” he said. “We just fall apart.”
Atul Gawande • Being Mortal: Medicine and What Matters in the End
That brings us back to hormones. Your lack of growth hormone (GH) is limiting the natural process of autophagy. And as your GH levels continue to sputter along, your tissue continues to degenerate. It’s why you have more aches and pains. Why food seems to make you fatter than it used to.