400 mcg is where you have a transcendental or mystical experience. At this dose or higher, it is critical to have qualified supervision in the form of a guide. “Transcendental” here roughly means “the feeling or the awareness that you are connected not only to other people but to other things and to living systems.” More on this later. 200 mcg can ... See more

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Z-drugs also don’t have much of an anti-anxiety effect and so don’t promote psychological dependence as powerfully as the benzodiazepines. I know this lack of tranquillizing effect from personal experience. When I first took a zopiclone tablet on the night flight back from Atlanta to London, it didn’t seem to be working. After about half an hour I

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