AlphaFold 3's 3D protein shapes + a tiny neural net trained on 633 binders & 51k non‑binders trimmed NetMHCIIpan’s error by 11 % for one class of MHC‑II molecules 📉
Structure > sequence with little data but only tested on HLA‑DRB1
A sign of a bigger trend, or a niche win? 🧬🤔