The organoids phenocopied physiological responses of endometrial epithelium to hormones, including increased cell proliferation under estrogen and maturation upon progesterone. Moreover, the human endometrial organoids replicated the menstrual cycle under hormonal treatment at both the morpho-histological and molecular levels. Together, we... See more

The organoids phenocopied physiological responses of endometrial epithelium to hormones, including increased cell proliferation under estrogen and maturation upon progesterone

Primary endometrial epithelial cells cultured on hard plastic (i.e. polystyrene) dishes rapidly undergo de-differentiation (Zhou et al. , 2022) and, in the presence of serum, further lose physiological attributes (Ghosh and Sengupta, 1995) and epithelial barrier integrity, and have increased cellular senescence by the third cell passage (Arnold et... See more