DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
pmc.ncbi.nlm.nih.gov
DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
A revolutionary approach to defeating cancer: Dr. Patrick Soon-Shiong unveils a game-changing strategy
In a riveting discussion, Dr. Patrick Soon-Shiong, a pioneering surgeon and biotech innovator, laid out a bold, chess-like strategy to outsmart cancer—an enemy he describes as diabolically clever, hiding from the... See more
Camusx.comA high TMB and IFNγ-related gene expression were not correlated and each independently predicted response, as reported previously (Cristescu et al., 2018; Rozeman et al., 2021). When combined, they best predicted response to anti-PD1-based therapy, over and above basic clinical factors (AUC, 0.84). However, this model was better at predicting good... See more
Article Multiomic profiling of checkpoint inhibitor-treated melanoma ...
The 10 biggest cancer papers of the last 10 years (in my opinion)
1. Blocking PD1 activates the immune response against cancer - especially if the cancer has more mutations
https://t.co/rBCVRcDfvo https://t.co/eG8CZ4kF7r