Wei Xuan Tan

In more scientific terms, these drugs have multiple modes of action, including:

• in the pancreas (insulin secretion goes up, glucagon secretion goes down to lower blood sugar levels; stomach emptying and gut motility go down to give you a longer feeling of fullness),


• in the liver (reduced glucose production; similar to metformin, a popular and cheap d

... See more

GLP-1 hormone may one day be regarded as the peptide that accidentally decoded the body, the mind, and basis of human health

A majority of people prescribed GLP-1 drugs stop using it within the first year. Maybe it’s the side effects. Maybe they miss drinking and don’t appreciate the nausea. Maybe they can’t afford the drugs. Maybe they stop after they hit their target weight. Maybe people just don’t like injectables.

Heavier people have more fat around their throat and upper respiratory tract, which makes it harder for some of them to breathe when they’re lying down. Any intervention that burns fat around the throat—whether it’s a drug, bariatric surgery, or a diet—should automatically help many people’s sleep.

Anything that treats obesity ought to automatically reduce that cancer risk

That I was born in the capital of the world’s richest country is one of the greatest strokes of luck in my life—a pure accident of timing and gametes. There is no way to pay back this good fortune, and wallowing in guilt over it would do nothing, either. The quiet miracle of charity and global aid is that the uneven distribution of global wealth cr... See more

The benefits of exercise seem too broad for any one therapy to mimic