Sublime
An inspiration engine for ideas
Today, we report Germinal, a method for efficient de novo antibody design, with @santimillef and @SynBioGaoLab.
Germinal achieves success rates of 4-22% across diverse epitopes.
We make the work fully open, without doing lame things like posting a preprint without methods. 🧵... See more
NIST AI 600-1 - Artificial Intelligence Risk Management Framework: Generative Artificial Intelligence Profile
The document provides a profile of risks unique to or exacerbated by generative artificial intelligence (GAI) and offers actions to manage these risks.
airc.nist.gov
"xTrimoABFold: De novo Antibody Structure Prediction without MSA" has been updated
Combines a PLM trained on antibodies w/ the NN from AlphaFold2. Authors don't hold back: they call it "the most accurate antibody structure prediction model in the world"
https://t.co/t38mPMi9vB... See more
Who wants to combine Evo (our DNA foundation model) and bridge RNA recombinases to demonstrate genome-scale design in living cells?
Patrick Hsux.com
Biotechnologists are increasingly planning not only to engineer microbes in the lab — but to then release them into the field.
These microbes can fix nitrogen for plants or clean up pollutants. Good or bad, this review is the most substantive piece ever written on the... See more
@jrkelly once sat me down in a boardroom of the Mecca that is Ginkgo Bioworks and made the case that the "market (e.g. invisible hand of economics)" hasn't yet shaken out any other than a handful of assays that can be qualified as routine assays (e.g. plasmid sequencing).
This (to my chagrin) was an omen for my time... See more
SynBioStrainFinder: A microbial strain database of manually curated CRISPR/Cas genetic manipulation system information for biomanufacturing
recommend CRISPR tools for microbial strains
https://t.co/KACHjf1YkO
good papersx.comThe ability of molecular biologists to control DNA has relied on enzymes derived from the phage-microbe arms race. In this new work, we systematically mined thousands of new serine integrases (LSRs) and developed them for human genome editing. 🧬
https://t.co/tjJKBvRPYc
Patrick Hsux.com