Sublime

AI discovered wholly new proteins before it could count the ‘r’s in ‘strawberry’, which makes it neither vaporware nor a demigod but a secret third thing.

We all know “startups are hard,” but I think we tend to imagine that this difficulty is bounded, contained, modelable, a bit like running a marathon: yes, legs and lungs hurt, but that’s normal and appropriate, and we know the route, the distance, and that there’s a finish line. This is a kind of difficulty we can contend with without losing... See more

I’ve spent the last three years pregnant, breastfeeding, or trying to conceive. I want more children, and I want close age gaps, and I want to write a book, and go to more parties, and keep publishing this newsletter. I still feel creative impulses, but they don’t always translate neatly to tangible output anymore. In fact, I would say they rarely... See more