Sublime
An inspiration engine for ideas
Fireside Chat: A Plan for Humanity with Bryan Johnson
youtube.comAt first I didn't realize how big this was, until I read the fine print: TLDR with the insights baked in:
OpenAI has developed a novel language model called GPT-4b micro, specifically designed for protein engineering in collaboration with Retro Biosciences, a longevity research company backed by Sam Altman's $180 millio... See more
David Shapiro ⏩x.comAre Blockchains Decentralized? Unintended Centralities in Distributed Ledgers
The report investigates the true decentralization of blockchains, highlighting various forms of centralization, vulnerabilities in consensus protocols, and the implications for security and immutability in networks like Bitcoin and Ethereum.
blog.trailofbits.comMercer_Pub 248
The study describes the development of a continuous evolution system to engineer small degron tags that can be inserted into endogenous genes and selectively degrade proteins using specific small molecules.
LinkJeff Karp is a scientist inspired by elegance … and jellyfish. As an associate professor at Harvard Medical School, Karp’s research focuses on using bio-inspiration—inspiration from nature—to develop new solutions for all types of medical challenges. His self-named Karp Lab has developed innovations such as a device inspired by jellyfish tentacles
... See moreRohit Bhargava • Non-Obvious 2017: How To Think Different, Curate Ideas and Predict The Future
Today we report in @NatureBiotech the development of dual-AAV in vivo delivery systems for prime editors that can support efficient prime editing in multiple organs such as brain, liver, and heart.
1/4 https://t.co/lSInTkYBiv
Malone and Verma saw that it might be possible to get around this problem by using mRNA instead of DNA to instruct the body to make a therapeutic protein. mRNA could not be incorporated into a patient’s genomic DNA, avoiding the possibility of a permanent and unwelcome change.
Thomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
