Sublime
An inspiration engine for ideas
Most competitive spaces in genetic medicine
Per an Evercore ISI analysis out today crunching 170+ companies and 800+ drugs:
1. Duchenne muscular dystrophy (50 programs)
2. ALS (24)
3. Cystic fibrosis (24)
4. Huntington's (18)
5. Alzhei... See more
Andrew Dunnx.com
The ability of molecular biologists to control DNA has relied on enzymes derived from the phage-microbe arms race. In this new work, we systematically mined thousands of new serine integrases (LSRs) and developed them for human genome editing. 🧬
https://t.co/tjJKBvRPYc
Patrick Hsux.comBiotech
Michael Tier • 1 card
This 2018 study found that 80% of the “most transformative” medicines approved for clinical use by the FDA could be traced back to one or several basic discoveries, which occurred on average three decades before approval! https://t.co/bdQlvdsPeg... See more
In 1953, aged 27, Paul Janssen set up a pharma company that would grow into one of the world's largest. Over his career, Janssen and his team brought >70 drugs to market.
Yet, today's drug hunters are likely to retire before discovering even one new medicine. What changed?🧵 https://t.co/NQo6EdnkfE
Discovery
Katharina Sommerkamp • 5 cards
Introducing Medchem, an open source Python library for molecular filtering and prioritization.
It includes hundreds of molecular filters, alerts, and rules, both established and novel.
Read the blog by @HadiM_ for more details: https://t.co/kjUAVLh5l3
datamol.iox.com