Sublime
An inspiration engine for ideas
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I think the era where Big Pharma needs internal Discovery is over. There is just too much innovation outside to fill Big Pharma pipelines many times over.
Going forward, Big Pharma should take the best discovery scientists & integrate them w/ the BD team.
Jing Liang đşđŚx.comPhase II and phase III failures: 2013â2015 - Nature Reviews Drug Discovery
Richard K. Harrisonnature.com
đŹMust-Read: PDGrapher turns phenotypeâdriven discovery into an inverse problem:
instead of predicting how every perturbation might change a cell, it directly predicts the minimal set of genes to hit to obtain a desired, healthy expression profile
Up to âĄď¸25âŻĂ fasterâĄď¸ than simâthenâsearch... See more
Pharmaceutical R&D is on death's doorstep and its current rebound is fragile and temporary.
Returns are already below the cost of capital, and any additional harms to profitability will drain the life-blood of the future, instantly snuffing out biomedical progress. https://t.co/MSpWL31xT2
Anyone interested in starting or ramping up in generative chemistry should read this paper and share it with their friends, students, and unrelated medicinal and computational chemists to help them get into the field.
This is probably the most concise and useful review of generative AI in small molecule chemistry, which takes 20-30... See more
@salonium and @JacobTref podcast episode on lenacapavir
Barry Werth's books on Vertex (about their successful forays into making drugs for cystic fibrosis, HIV, Hep C)
For Blood and Money by Nathan Vardi is the history of Imbruvica's development (one of the major leukemia/lymphoma drugs... See more
Alex Kesinx.com
Today we report in @NatureBiotech the development of dual-AAV in vivo delivery systems for prime editors that can support efficient prime editing in multiple organs such as brain, liver, and heart.
1/4 https://t.co/lSInTkYBiv
(1/4) Molecular glue degraders are captivating drug discovery, but how might drug resistance emerge? Read our new preprint! We identify themes of degrader resistance involving neosubstrates. #TPD https://t.co/5CQIKZZ0iA https://t.co/agq5mx1fc8