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A Crack In Creation: Gene Editing and the Unthinkable Power to Control Evolution
amazon.com
The CRISPR-Cas9 bacterial defense complex (left) has a guide RNA that recognizes a target phage DNA sequence and a tracrRNA that base-pairs with the guide RNA and holds on to the Cas9 protein. Cas9 then cleaves both strands of the DNA. An engineered form of CRISPR-Cas9 used for genome editing (right) has the two natural RNAs fused to form a single-
... See moreThomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
Several groups of scientists made mutations in the Cas9 protein that incapacitated its DNA-cutting activity but did not interfere with its ability to bind a single-guide RNA. They dubbed their creation “Dead Cas9” for short. They now found that by coupling a variety of other proteins to Dead Cas9, they could deliver those proteins to specific sites
... See moreThomas R. Cech • The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets
Erin Kissane, Writer/Researcher - XOXO Festival (2024)
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John Fagan is a molecular biologist who for more than twenty years was funded by the National Institutes of Health to conduct genetic engineering research. But in 1994, he returned more than $600,000 to the NIH and withdrew his proposals for another $1.25 million. Then he launched a global campaign to alert the public about the hazards of genetic e
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