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A Crack In Creation: Gene Editing and the Unthinkable Power to Control Evolution
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There was one competition in Doudna’s life that stands out for becoming heated and then bitter: the race in 2012 to show how CRISPR could edit the genes of humans.
Walter Isaacson • The Code Breaker
In the history of science, there are few real eureka moments, but this came pretty close. “It wasn’t just some gradual process where it slowly dawned on us,” Doudna says. “It was an oh-my-God moment.” When Jinek showed Doudna his data demonstrating that you could program Cas9 with different guide RNAs to cut DNA wherever you desired, they actually
... See moreWalter Isaacson • The Code Breaker
“Perhaps the most exciting finding of this study is that Dicer can be reengineered,” their 2006 paper noted.4 It was a very useful discovery. It permitted researchers to use RNA interference to turn off a wide variety of genes, both to discover what each gene does and to regulate its activity for medical purposes.
Walter Isaacson • The Code Breaker
A gene editing tool This amazing little system, it quickly became clear, had a truly momentous potential application: the crRNA guide could be modified to target any DNA sequence you might wish to cut. It was programmable. It could become an editing tool. The study of CRISPR would become a vivid example of the call-and-response duet between basic
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