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Isabella was the daughter of John II of Castile and his second wife, Isabella of Portugal
Isabella I | Biography, Reign, & Facts | Britannica
Isabella was born in 1451, into a world in which women fought for every shred of political power. But from an early age, Isabella was viewed by her father John II of Castile as a means of expanding Castilian territory in pursuit of the elusive goal of uniting Spain. She was first betrothed to an Aragonese prince at age six — her future husband... See more
Ferdinand and Isabella: The Marriage That Unified Spain | TheCollector
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Isabel Allende • Violeta [English Edition]: A Novel

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Isabella demonstrated exceptional political skill even before her marriage to Ferdinand in 1469. She secretly married Ferdinand against the wishes of her half-brother King Henry IV, who had intended her to marry the King of Portugal. This defiance required careful planning and political maneuvering, including obtaining a (likely forged) papal... See more
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At the same time that Ferdinand headed south, Isabella’s health began to decline. She would feel weak for months at a time and then recover, only to grow weary once again. In the fall of 1504, she became bedridden, suffering from dropsy (as edema was called then) and fever. On November 26 of that year, Isabella died at the age of fifty-three. Her
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