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Mercer_Pub 248
The study describes the development of a continuous evolution system to engineer small degron tags that can be inserted into endogenous genes and selectively degrade proteins using specific small molecules.
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Anyone else tracking the non antibody/small molecule space in public markets? Like we've seen with the microbiome space, we'll see the tail or head winds in related modalities for years to come! 🧬
Especially interested in macrocycles with @Merck, BMS, @Cothera, Bicycle, Revolution Medicines, Chugai all in clinic. ___LI... See more
Physician scientist @RonDePinho has co-founded several biotech companies incl 2 cancer drug companies w/FDA-approved products (KPTI & AVEO) He shared advice 4 academics starting a biotech company incl capital funding needs 4 IND-enabling studies $12-$15M cost/asset small molecule https://t.co/EgGTi6xj4E
Today we report in @NatureComms the development of compact zinc-finger base editors that edit mitochondrial or nuclear DNA in human cells and in animals, building on our previous development of TALE BEs that enabled the first precise editing of mtDNA. 1/8
https://t.co/bK2fi3yJgi... See more