Sublime

You may have heard of this gene, which is called APOE, because of its known effect on Alzheimer’s disease risk. It codes for a protein called APOE (apolipoprotein E) that is involved in cholesterol transport and processing, and it has three variants: e2, e3, and e4. Of these, e3 is the most common by far, but having one or two copies of the e4 vari

When I look at a patient’s blood panel for the first time, my eyes immediately dart to two numbers: apoB and Lp(a). I look at the other numbers, too, but these two tell me the most when it comes to predicting their risk of ASCVD. ApoB not only tells me the concentration of LDL particles (which, you’ll recall, is more predictive of disease than the

Harvard Medical School was and is at the forefront of the neuroscience revolution,

While there are seven statins on the market, I tend to start with rosuvastatin (Crestor) and only pivot from that if there is some negative effect from the drug (e.g., a symptom or biomarker). My goal is aggressive: as rationalized by Peter Libby, I want to knock someone’s apoB concentration down to 20 or 30 mg/dL, about where it would be for a chi

distinguishing thing about disease-causing (atherogenic) lipoproteins is a surface protein, called apoB100, apoB for short. Most apoB protein is found on LDL particles but apoB is also present on other lipoprotein particles: very low density and intermediate density lipoproteins (VLDL and IDL) and Lp(a). The measurement of apoB accounts for all of