Juan Orbea

While Adobe has positioned itself as a leader in building software for professional designers, Canva set out to position its product as the go-to solution for everybody else.

Listen to Henry tell his story from learning about effective altruism to making the decision to giving away 50% of his income - he also shares a fascinating story about getting infected with malaria for medical research.

Within the AI space, she is the female founder who has raised most VC funding.

Chart by Lloyd WattsCochlea: Sense organ of hearing. Detection of spectral edges and calibrating for noise levels. VNTB: Ventral Nucleus of the Trapezoid Body. Computing inter-aural time difference (difference in time of arrival between the two ears, used to tell where a sound is coming from).LSO: Lateral Superior Olive. The brain is not one huge... See more

They combine the love of freedom of team BTC with the moral energy of team NYT and the organization of team CCP, and give us the best benefits of all three (plus a level of international appeal greater than any of the three) and avoid the worst parts.

3) Pushing against regulatory conservatism in general, by increasing the chance that there's some jurisdiction that will let you do any particular thing. Allowing people to opt into network states that accept higher levels of risk could be a successful strategy for pushing against this.

But here’s the magic few people ever talk about …We’ve created more than $1.5 billion in value to Upfront from just 6 deals that WERE NOT immediately up and to the right.The beauty of these businesses that weren’t immediate momentum is that they didn’t raise as much capital (so neither we nor the founders had to take the extra dilution), they took... See more

The last 12 years were "up and to the right". It’s easy to make IRRs work really well in a 12-year bull market but VCs have to make money in good markets and bad.