Collections

Startups• 173
Alex Wittenberg

When startups start taking off, the founders usually can't tell what's changed. It's some combination of all the random things they did to make it ta

Enzyme Biomodeling• 1
Juan Orbea
Artificial Intelligence• 244
sari

Most AI backlash is economic anxiety coated in a veneer of social justice. Alfalfa farming consumes 19 times the water that data centers do; there’s n

“Diffusion lag” reflects a lack of product-market fit. Even AI optimists are still hitting practical roadblocks. That’s why detailed case studies are

Here are some things I’ve asked chatgpt recently: “why is Toblerone so popular at airport duty-free stores?” “give me a recipe for a chickpea tagine

CLAUDE.md growth: why it happens and how to fix it

synthetic biology • 7

Synthetic biology is a field of science that involves redesigning organisms for useful purposes by engineering them to have new abilities. Synthetic biology researchers and companies around the world are harnessing the power of nature to solve problems in medicine, manufacturing and agriculture.

Juan Orbea

Dallas-based Colossal Biosciences, the self-described de-extinction company behind the woolly mammoth and thylacine, today announced that it is spinni

computational biology• 2
Juan Orbea
Complex Systems• 42

Complex systems are systems where the collective behavior of their parts entails emergence of properties that can hardly, if not at all, be inferred from properties of the parts.

Jason Badeaux

“leverage points.” These are places within a complex system (a corporation, an economy, a living body, a city, an ecosystem) where a small shift in on

Future of Wealth Management and Investing• 23
Timothy Shih
investing wisdom• 58
Daniel Bakalarz
Investment thesis• 17
Darren LI

Instead, Professor Kahneman favored an alternative that he termed “adversarial collaboration.” When people who disagree work together to test a hypoth

Julian Shapiro• 1

Writings & Content by Julian Shapiro.

Juan Orbea
Koko Xu• 1

Writings and content by Koko Xu.

Juan Orbea
deep-tech• 33
Juan Orbea
Early Career Advice• 59

Career advice for young people and/or people early on in their career

Kassen Qian

Advice I would give to a college freshman: These next four years, one of your main goals should be to figure out how not to have the rest of your lif

Life• 267

philosophical content pointing us towards living a meaningful life

Prashanth Narayan

We require heroism of our entertainers. We want them sacrificing themselves to a certain ultimate degree of input. No one can sing this loud, and yet

i stayed and looked at the sleeping dead duck. due to a lifetime of zoloft, i cannot cry. my eyes dont make tears. but i can feel the feeling of being

We're in a cycle of constant outrage (which is not to downplay how actually outrageous the time we're living in is), pushed by the insatiable need for

Life Advice• 83
unoptimal

And I came to believe that heroism is neither being perfect, nor doing something spectacular. In fact, it’s just the opposite: it’s regular, flawed hu

neurotech• 11
Juan Orbea
Real Learning• 1
Juan Orbea
Future of Education and Learning• 321
sari

In large part this is because education, like most social systems, is slow to adapt, iterate, and evolve to be relevant for changing times. The glacia

generative AI is but the latest in a line of innovations that draws attention to the flaws of the modern education system, leaving us to question how

The humanities, rightly understood, are the things that technology cannot take away or substitute for. Of course, I don’t mean ‘humanities’ in the way

Learning Science• 3
Bhaumik Patel
Investment memo• 19
Darren LI