Mixing uses and density, in general, work best for individuals or families that are comfortable interacting with others  and who don’t crave large tracts of personal space. 

People in mixed-use environments may feel less of a sense of isolation  as places abound to walk, drink a cup of coffee, buy a loaf of bread, etc. where one might see other people and/or interact with them, as opposed to staying cooped up in their house or apartment because there is nothing to do outside of it.

Studies show that the presence of more people and bustle can translate into safer streets , as people are less likely to commit crimes with so much activity happening around them. 

Mixed use neighborhoods are usually more compact, with less sprawl. With density come benefits like new and exciting businesses and a lively street with a lot of visual interest – where  residents no longer have to get into their car for every errand or social engagement .